Alkynylsilanes as convenient precursors for the stereoselective synthesis of (E)-disubstituted alkenes

被引：0
|
作者：
Zhao, H [1 ]
Cai, MZ [1 ]
机构：
[1] Jiangxi Normal Univ, Dept Chem, Nanchang 330027, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2002年 / 12期
关键词：
hydromagnesiation; (E)-disubstituted alkene; stereoselective synthesis;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydromagneisation of alkynylsilanes 1 gives (Z)-alpha-silylvinyl Grignard reagents 2, which are reacted with alkyl iodides or aryl iodides in the presence of Cul or Pd(PPh3)(4) catalysts to afford (Z)-1,2-disubstituted vinylsilanes 3 in good yields. Intermediates 3 can undergo a desilylation reaction to give (E)-disubstituted alkenes 4 in high yields.
引用
收藏
页码：608 / 610
页数：3
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