Alkynylsilanes as convenient precursors for the stereoselective synthesis of (E)-disubstituted alkenes

被引：0

作者：

Zhao, H ^{[1
]}

Cai, MZ ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Dept Chem, Nanchang 330027, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2002年 / 12期

关键词：

hydromagnesiation; (E)-disubstituted alkene; stereoselective synthesis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydromagneisation of alkynylsilanes 1 gives (Z)-alpha-silylvinyl Grignard reagents 2, which are reacted with alkyl iodides or aryl iodides in the presence of Cul or Pd(PPh3)(4) catalysts to afford (Z)-1,2-disubstituted vinylsilanes 3 in good yields. Intermediates 3 can undergo a desilylation reaction to give (E)-disubstituted alkenes 4 in high yields.

引用

页码：608 / 610

页数：3

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