Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury

被引：11
|
作者：
Hu, Pan-Pan
Bao, Jing-Fu
Li, Aiqing
机构：
[1] Southern Med Univ, Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Organ Failure Res, Guangzhou 510515, Peoples R China
[2] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangdong Prov Key Lab Renal Failure Res, Guangzhou 510005, Peoples R China
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 116卷
关键词：
Acute kidney injury; Fibroblast growth factor-23; alpha-Klotho; RENIN-ANGIOTENSIN SYSTEM; VITAMIN-D METABOLISM; SOLUBLE KLOTHO; TUBULOINTERSTITIAL FIBROSIS; MINERAL METABOLISM; REDUCES APOPTOSIS; OXIDATIVE STRESS; FGF23; EXPRESSION; EARLY BIOMARKER; BETA-KLOTHO;
D O I：
10.1016/j.metabol.2020.154435
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute kidney injury is a global disease with high morbidity and mortality. Recent studies have revealed that the fibroblast growth factor-23-alpha-Klotho axis is closely related to chronic kidney disease, and has multiple biological functions beyond bone-mineral metabolism. However, although dysregulation of fibroblast growth factor-23 -alpha-Klotho has been observed in acute kidney injury, the role of fibroblast growth factor-23-alpha-Klotho in the pathophysiology of acute kidney injury remains largely unknown. In this review, we describe recent findings regarding fibroblast growth factor-23-alpha-Klotho, which is mainly involved in inflammation, oxidative stress, and hemodynamic disorders. Further, based on these recent results, we put forth novel insights regarding the relationship between the fibroblast growth factor-23-alpha-Klotho axis and acute kidney injury, which may provide new therapeutic targets for treating acute kidney injury. (c) 2020 Elsevier Inc. All rights reserved.
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页数：11
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