Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury

Acute kidney injury is a global disease with high morbidity and mortality. Recent studies have revealed that the fibroblast growth factor-23-alpha-Klotho axis is closely related to chronic kidney disease, and has multiple biological functions beyond bone-mineral metabolism. However, although dysregulation of fibroblast growth factor-23 -alpha-Klotho has been observed in acute kidney injury, the role of fibroblast growth factor-23-alpha-Klotho in the pathophysiology of acute kidney injury remains largely unknown. In this review, we describe recent findings regarding fibroblast growth factor-23-alpha-Klotho, which is mainly involved in inflammation, oxidative stress, and hemodynamic disorders. Further, based on these recent results, we put forth novel insights regarding the relationship between the fibroblast growth factor-23-alpha-Klotho axis and acute kidney injury, which may provide new therapeutic targets for treating acute kidney injury. (c) 2020 Elsevier Inc. All rights reserved.