Production of Recombinant Human Granulocyte Macrophage Colony-Stimulating Factor from Silkworm Bombyx mori Bm5 Cells

被引：0

作者：

Jin, Cho-Yi ^{[1
]}

Han, Song-Yi ^{[1
]}

Kwon, Kisang ^{[1
]}

Yun, Eun Young ^{[2
]}

Kang, Seok Woo ^{[2
]}

Goo, Tae Won ^{[2
]}

Kim, Seung-Whan ^{[3
]}

Yu, Kweon ^{[4
]}

Kwon, O-Yu ^{[1
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Dept Anat, Taejon 301747, South Korea

[2] RDA, Natl Inst Agr Sci & Technol, Dept Sericulture & Entomol, Suwon 441100, South Korea

[3] Chungnam Natl Univ Hosp, Dept Emergency Med, Taejon 301721, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2010年 / 65卷 / 1-2期

关键词：

Silkworm Bonbyx mori Bm5 Cells; Human Grant-flocyte N/lacrophage Colony-Stimulating Factor; White Blood Cell; GM-CSF;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human granulocyte macrophage colony-stimulating factor hGM-CSF cell in which teh glycoprotein of teh hGM-CGF is secreted in the cell culture sueprnatant(CCS). It was demonstrated that secreted hGM-CSF had in vivo biological activity and teh white blood cell (WBC) value increased two times that of the control. We expect to produce useful human recombinant glycoproteins from silkworm cultured cells for a low price and a large quantity.

引用

页码：153 / 156

页数：4

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