Production of Recombinant Human Granulocyte Macrophage Colony-Stimulating Factor from Silkworm Bombyx mori Bm5 Cells

被引：0

作者：

Jin, Cho-Yi ^{[1
]}

Han, Song-Yi ^{[1
]}

Kwon, Kisang ^{[1
]}

Yun, Eun Young ^{[2
]}

Kang, Seok Woo ^{[2
]}

Goo, Tae Won ^{[2
]}

Kim, Seung-Whan ^{[3
]}

Yu, Kweon ^{[4
]}

Kwon, O-Yu ^{[1
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Dept Anat, Taejon 301747, South Korea

[2] RDA, Natl Inst Agr Sci & Technol, Dept Sericulture & Entomol, Suwon 441100, South Korea

[3] Chungnam Natl Univ Hosp, Dept Emergency Med, Taejon 301721, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2010年 / 65卷 / 1-2期

关键词：

Silkworm Bonbyx mori Bm5 Cells; Human Grant-flocyte N/lacrophage Colony-Stimulating Factor; White Blood Cell; GM-CSF;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human granulocyte macrophage colony-stimulating factor hGM-CSF cell in which teh glycoprotein of teh hGM-CGF is secreted in the cell culture sueprnatant(CCS). It was demonstrated that secreted hGM-CSF had in vivo biological activity and teh white blood cell (WBC) value increased two times that of the control. We expect to produce useful human recombinant glycoproteins from silkworm cultured cells for a low price and a large quantity.

引用

页码：153 / 156

页数：4

共 50 条

[31] STIMULATION OF HEMATOPOIESIS IN PRIMATES WITH RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
DONAHUE, RE
NIENHUIS, AW
WONG, GG
NATHAN, DG
CLARK, SC
JOURNAL OF BIOLOGICAL RESPONSE MODIFIERS, 1987, 6 (02): : 219 - 219
[32] EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
VADHANRAJ, S
KEATING, M
LEMAISTRE, A
HITTELMAN, WN
MCCREDIE, K
TRUJILLO, JM
BROXMEYER, HE
HENNEY, C
GUTTERMAN, JU
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (25): : 1545 - 1552
[33] INVIVO BIOLOGIC ACTIVITIES OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
VADHANRAJ, S
HITTELMAN, WN
BROXMEYER, HE
KEATING, M
URDAL, D
GUTTERMAN, JU
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1989, 554 : 231 - 240
[34] CLINICAL-STUDIES WITH RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
STEWARD, WP
SCARFFE, JH
BONNEM, E
CROWTHER, D
INTERNATIONAL JOURNAL OF CELL CLONING, 1990, 8 : 335 - 346
[35] POTENTIAL USES OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN CHILDREN
FURMAN, WL
CRIST, WM
AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1991, 13 (04): : 388 - 399
[36] Antineoplastics/granulocyte colony-stimulating factor/granulocyte-macrophage colony-stimulating factorPneumonitis: 5 case reports
Reactions Weekly, 1999, 742 (1) : 6 - 6
[37] HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN PEDIATRIC ONCOLOGY PRACTICE
FERENCZ, T
CSAKI, C
SCHULER, D
BORSI, JD
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1994, 11 (02) : 201 - 205
[38] PRODUCTION OF GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR BY CULTURED ASTROCYTES
OHNO, K
SUZUMURA, A
SAWADA, M
MARUNOUCHI, T
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (02) : 719 - 724
[39] Pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor: The effects of zidovudine
Aweeka, FT
Kwong, M
Mak, M
AlUzri, A
Affrime, M
Cutler, D
Kahn, J
Gambertoglio, JG
JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 36 (12): : 1107 - 1113
[40] RECOMBINANT HUMAN TNF INDUCES PRODUCTION OF GRANULOCYTE MONOCYTE COLONY-STIMULATING FACTOR
MUNKER, R
GASSON, J
OGAWA, M
KOEFFLER, HP
NATURE, 1986, 323 (6083) : 79 - 82

← 1 2 3 4 5 →