Palladium-catalyzed intramolecular decarboxylative allylic arylation of α-aryl-γ-methylidene-δ-valerolactones

被引：17
|
作者：
Shintani, Ryo [1 ]
Tsuji, Takaoki [1 ]
Park, Soyoung [1 ]
Hayashi, Tamio [1 ]
机构：
[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 10期
关键词：
ALLYLATION; ALKYLATION; INDOLES; INTERMEDIATE; CYCLIZATION; GENERATION; REAGENTS; ALCOHOLS; ACETATES; KETONES;
D O I：
10.1039/b924416f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed intramolecular decarboxylative cyclization of alpha-aryl-gamma-methylidene-delta-valerolactones, followed by olefin isomerization, has been developed to give fused polycyclic aromatic compounds under mild conditions. The process described here can be regarded as a formal decarboxylative allylic arylation without using a pre-formed organometallic nucleophile. The reaction can be conducted on a gram scale and the products thus obtained are further derivatized with ease.
引用
收藏
页码：1697 / 1699
页数：3
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