4′-Thionucleosides as Potent and Selective A3 Adenosine Receptor Ligands

被引：0
|
作者：
Sahu, Pramod K. [1 ]
Naik, Siddhi D. [1 ,2 ]
Mehdi, Sofia [1 ]
Jeong, Lak S. [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[2] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
来源：
CURRENT ORGANIC CHEMISTRY | 2016年 / 20卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
A(3) adenosine receptor; agonist; antagonist; 4 '-thionucleoside; structure-activity relationship; CL-IB-MECA; CELL-CYCLE ARREST; HIGHLY POTENT; CANCER CELLS; AGONIST; DERIVATIVES; ANTAGONISTS; APOPTOSIS; DESIGN; D-4'-THIOADENOSINE;
D O I：
10.2174/1385272819666150804000511
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A(3) adenosine receptors (ARs) have long been viewed as potential therapeutic targets due to their association with a variety of pathophysiological processes. Development of potent and selective A(3)AR nucleoside ligands has been an area of interest of medicinal chemists since last two decades. Various prime modifications made on N-6 and C-2 position of the adenosine moiety has led to the discovery of some of the most efficacious A3AR ligands. This review is an account of the development of 4'-thionucleosides as A(3)AR agonists and antagonists by various chemical modifications on the thionucleoside template.
引用
收藏
页码：930 / 938
页数：9
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