4′-Thionucleosides as Potent and Selective A3 Adenosine Receptor Ligands

被引：0

作者：

Sahu, Pramod K. ^{[1
]}

Naik, Siddhi D. ^{[1
,2
]}

Mehdi, Sofia ^{[1
]}

Jeong, Lak S. ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[2] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

来源：

CURRENT ORGANIC CHEMISTRY | 2016年 / 20卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

A(3) adenosine receptor; agonist; antagonist; 4 '-thionucleoside; structure-activity relationship; CL-IB-MECA; CELL-CYCLE ARREST; HIGHLY POTENT; CANCER CELLS; AGONIST; DERIVATIVES; ANTAGONISTS; APOPTOSIS; DESIGN; D-4'-THIOADENOSINE;

D O I：

10.2174/1385272819666150804000511

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A(3) adenosine receptors (ARs) have long been viewed as potential therapeutic targets due to their association with a variety of pathophysiological processes. Development of potent and selective A(3)AR nucleoside ligands has been an area of interest of medicinal chemists since last two decades. Various prime modifications made on N-6 and C-2 position of the adenosine moiety has led to the discovery of some of the most efficacious A3AR ligands. This review is an account of the development of 4'-thionucleosides as A(3)AR agonists and antagonists by various chemical modifications on the thionucleoside template.

引用

页码：930 / 938

页数：9

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