A Fatal Complication of Liver Transplant: Posttransplant Lymphoproliferative Disease

被引：0
|
作者：
Hizarcioglu-Gulsen, Hayriye [1 ]
Gumus, Ersin [1 ]
Demir, Hulya [1 ]
Saltik-Temizel, Inci N. [1 ]
Varan, Ali [2 ]
Dincer, Hilmi Anil [3 ]
Dogrul, Ahmet Bulent [3 ]
Ozen, Hasan [1 ]
机构：
[1] Hacettepe Univ, Fac Med, Dept Pediat Gastroenterol Hepatol & Nutr, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Pediat Oncol, Ankara, Turkey
[3] Hacettepe Univ, Fac Med, Dept Gen Surg, Ankara, Turkey
来源：
EXPERIMENTAL AND CLINICAL TRANSPLANTATION | 2022年 / 20卷 / 05期
关键词：
Cytomegalovirus; Epstein-Barr virus; Lymphoma; Tacrolimus;
D O I：
10.6002/ect.PediatricSymp2022.O33
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Immunosuppressive therapy is a double-edged sword and causes a risk for some complications, such as opportunistic infections and posttransplant lymphoproliferative disease. The most likely risk factors for posttransplant lymphoproliferative disease are Epstein-Barr virus serology mismatch, prolonged and high viral load for Epstein-Barr virus, higher doses of immunosuppressive therapy, and cytomegalovirus infection. Transplant recipients who are seropositive for Epstein-Barr virus show a lower risk for posttransplant lymphoproliferative disease than seronegative recipients. Here, we present a 3.5-year-old boy who was seropositive for Epstein-Barr virus and developed posttransplant lymphoproliferative disease 18 months after liver transplant with a previous history of cytomegalovirusrelated pneumatosis intestinalis.
引用
收藏
页码：102 / 104
页数：3
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