A Fatal Complication of Liver Transplant: Posttransplant Lymphoproliferative Disease

被引：0

作者：

Hizarcioglu-Gulsen, Hayriye ^{[1
]}

Gumus, Ersin ^{[1
]}

Demir, Hulya ^{[1
]}

Saltik-Temizel, Inci N. ^{[1
]}

Varan, Ali ^{[2
]}

Dincer, Hilmi Anil ^{[3
]}

Dogrul, Ahmet Bulent ^{[3
]}

Ozen, Hasan ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Pediat Gastroenterol Hepatol & Nutr, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Pediat Oncol, Ankara, Turkey

[3] Hacettepe Univ, Fac Med, Dept Gen Surg, Ankara, Turkey

来源：

EXPERIMENTAL AND CLINICAL TRANSPLANTATION | 2022年 / 20卷 / 05期

关键词：

Cytomegalovirus; Epstein-Barr virus; Lymphoma; Tacrolimus;

D O I：

10.6002/ect.PediatricSymp2022.O33

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Immunosuppressive therapy is a double-edged sword and causes a risk for some complications, such as opportunistic infections and posttransplant lymphoproliferative disease. The most likely risk factors for posttransplant lymphoproliferative disease are Epstein-Barr virus serology mismatch, prolonged and high viral load for Epstein-Barr virus, higher doses of immunosuppressive therapy, and cytomegalovirus infection. Transplant recipients who are seropositive for Epstein-Barr virus show a lower risk for posttransplant lymphoproliferative disease than seronegative recipients. Here, we present a 3.5-year-old boy who was seropositive for Epstein-Barr virus and developed posttransplant lymphoproliferative disease 18 months after liver transplant with a previous history of cytomegalovirusrelated pneumatosis intestinalis.

引用

页码：102 / 104

页数：3

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