Ultrasensitive and ratiometric two-photon fluorescence imaging of Golgi polarity during drug-induced acute kidney injury

被引:29
|
作者
Wang, Hui [1 ]
Dong, Mingyan [1 ]
Wang, Hongtong [1 ]
Huang, Fang [1 ]
Li, Ping [1 ]
Zhang, Wei [1 ]
Zhang, Wen [1 ]
Tang, Bo [1 ]
机构
[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Minist Educ,Inst Biomed Sci,Key Lab Mol & Nano Pr, Jinan 250014, Peoples R China
基金
中国国家自然科学基金;
关键词
LIVING CELLS; STRESS; PH;
D O I
10.1039/d1cc01411k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We synthesized an ultrasensitive probe TP-Golgi for the two-photon ratiometric fluorescence imaging of Golgi polarity. Probe TP-Golgi possesses a large Stokes shift, excellent sensitivity and good selectivity to quantitatively detect environmental polarity. By application of TP-Golgi, we found that the Golgi polarity increased obviously in the kidneys of mice with AKI.
引用
收藏
页码:5838 / 5841
页数:4
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