One-Pot Aminoalkylation of Aldehydes: Diastereoselective Synthesis of Vicinal Diamines with Azaarylmethylamines

被引：8
|
作者：
Guan, Haixing [1 ]
Cao, Xianzhong [1 ]
Walsh, Patrick J. [2 ]
Mao, Jianyou [1 ]
机构：
[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China
[2] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 21期
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
STEREOSELECTIVE-SYNTHESIS; MANNICH REACTION; STEREOCONTROLLED SYNTHESIS; ORGANOMETALLIC REAGENTS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; AMINATIVE UMPOLUNG; LITHIUM AMIDES; ALPHA; IMINES;
D O I：
10.1021/acs.orglett.9b03287
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot synthesis of vicinal diamines with azaarylmethylamines and aldehydes is reported. A diverse array of vicinal diamines could be achieved in up to 92% yield with good to excellent diastereoselectivities (up to 20:1). The tandem reaction takes place under mild conditions and provides an alternative strategy for the synthesis of vicinal diamines.
引用
收藏
页码：8679 / 8683
页数：5
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