Carbocyclic 7-deazaguanine oxetanocin analogues

被引：0
|
作者：
Wu, JY [1 ]
Schneller, SW
Seley, KL
De Clercq, E
机构：
[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA
[2] Auburn Univ, Dept Chem, Auburn, AL 36849 USA
[3] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
HETEROCYCLES | 1998年 / 47卷 / 02期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of two carbocyclic 7-deazaguanosine oxetanocins structurally modified at the C-3' center and lacking the C-2' hydroxymethylene group is described. Neither of these target compounds showed antiviral activity against a battery of DNA and RNA viruses.
引用
收藏
页码：757 / 763
页数：7
相关论文
共 50 条
  • [41] Oligonucleotides containing 7-deazaguanine: The role of 7- and 8-methyl groups during the B-Z transition of DNA
    Seela, F
    Chen, YM
    COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1996, 61 : S112 - S113
  • [42] Synthesis and antitumor activity of phenyl carbocyclic oxetanocin and related compounds
    Maruyama, T
    Fukuhara, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1996, 44 (07) : 1407 - 1411
  • [43] Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases
    Wickramaratne, Susith
    Ji, Shaofei
    Mukherjee, Shivam
    Su, Yan
    Pence, Matthew G.
    Lior-Hoffmann, Lee
    Fu, Iwen
    Broyde, Suse
    Guengerich, F. Peter
    Distefano, Mark
    Scharer, Orlando D.
    Sham, Yuk Yin
    Tretyakova, Natalia
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (45) : 23589 - 23603
  • [44] Stereoselective route to oxetanocin carbocyclic analogues based on a [2+2] photocycloaddition to a chiral 2(5H)-furanone
    Rustullet, Albert
    Alibes, Ramon
    de March, Pedro
    Figueredo, Marta
    Font, Josep
    ORGANIC LETTERS, 2007, 9 (15) : 2827 - 2830
  • [45] Oxidation of 7-deazaguanine by one-electron and oxo-transfer oxidants: Mismatch-dependent electrochemistry and selective strand scission
    Yang, IV
    Thorp, HH
    INORGANIC CHEMISTRY, 2001, 40 (07) : 1690 - 1697
  • [46] Ring-expanded analogues of natural oxetanocin
    Nair, V
    Chun, BK
    Vadakkan, JJ
    TETRAHEDRON, 2004, 60 (45) : 10261 - 10268
  • [47] ANTI-HERPESVIRUS ACTIVITY OF CARBOCYCLIC OXETANOCIN-G INVITRO
    NISHIYAMA, Y
    YAMAMOTO, N
    YAMADA, Y
    DAIKOKU, T
    ICHIKAWA, YI
    TAKAHASHI, K
    JOURNAL OF ANTIBIOTICS, 1989, 42 (12): : 1854 - 1859
  • [48] Enzymatic synthesis of D- and L-carbocyclic oxetanocin-A.
    Gumina, G
    Bondada, L
    Nair, R
    Chu, CK
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U201 - U201
  • [49] Pyrene and bis-pyrene DNA nucleobase conjugates: excimer and monomer fluorescence of linear and dendronized cytosine and 7-deazaguanine click adducts
    Mei, Hui
    Ingale, Sachin A.
    Seela, Frank
    TETRAHEDRON, 2013, 69 (23) : 4731 - 4742
  • [50] SYNTHESIS OF THE CARBOCYCLIC OXETANOCIN-A1 AND ITS RELATED-COMPOUNDS
    SATO, Y
    HORII, T
    MARUYAMA, T
    HONJO, M
    SIXTEENTH SYMPOSIUM ON NUCLEIC ACIDS CHEMISTRY, 1989, 21 : 125 - 126
12345