Hypersampsones S-W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

被引：19
|
作者：
Tian, Wen-Jing [1 ,3 ]
Qiu, Yu-Qin [2 ]
Jin, Xiao-Jie [4 ]
Chen, Hai-Feng [1 ]
Yao, Xiao-Jun [4 ,5 ]
Dai, Yi [2 ]
Yao, Xin-Sheng [2 ,3 ]
机构：
[1] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
[3] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[4] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
[5] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 56期
关键词：
POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; SKELETON; CORES;
D O I：
10.1039/c5ra26332h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Five new polycyclic polyprenylated acylphloroglucinols (1-5) with a bicyclo[3.3.1] nonane skeleton, along with five known analogues (6-10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1-5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXR alpha transcriptional-inhibitory activities and cytotoxicity against HeLa cells.
引用
收藏
页码：50887 / 50894
页数：8
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