Hypersampsones S-W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

被引：19

作者：

Tian, Wen-Jing ^{[1
,3
]}

Qiu, Yu-Qin ^{[2
]}

Jin, Xiao-Jie ^{[4
]}

Chen, Hai-Feng ^{[1
]}

Yao, Xiao-Jun ^{[4
,5
]}

Dai, Yi ^{[2
]}

Yao, Xin-Sheng ^{[2
,3
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[4] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[5] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 56期

关键词：

POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; SKELETON; CORES;

D O I：

10.1039/c5ra26332h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five new polycyclic polyprenylated acylphloroglucinols (1-5) with a bicyclo[3.3.1] nonane skeleton, along with five known analogues (6-10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1-5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXR alpha transcriptional-inhibitory activities and cytotoxicity against HeLa cells.

引用

页码：50887 / 50894

页数：8

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