A High Expression of IL15 Receptor Alpha (IL15Rα) in Glioblastoma Microenvironment Enables IL15-Armored CAR T Cells to Modulate Tumor Immunosuppression and Improve Survival in Syngeneic Models

被引:0
|
作者
Zannikou, Markella [1 ]
Duffy, Joseph T. [2 ]
Levine, Rebecca N. [2 ]
Seblani, Maggie D. [2 ]
Liu, Iris [2 ]
Arrieta, Victor A. [2 ]
Sonabend, Adam M. [2 ]
Lee-Chang, Catalina [2 ]
Miska, Jason M. [2 ]
Balyasnikova, Irina V. [2 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Neurol Surg, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
478
引用
收藏
页码:226 / 227
页数:2
相关论文
共 37 条
  • [31] CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival
    Nie, Siyue
    Song, Yujie
    Hu, Kun
    Zu, Wei
    Zhang, Fengjiao
    Chen, Lixia
    Ma, Qiang
    Zhou, Zishan
    Jiao, Shunchang
    ONCOIMMUNOLOGY, 2024, 13 (01):
  • [32] B7H3 CAR V DELTA 2 GAMMA DELTA T CELLS ARMORED WITH A POTENT SECRETED IL15 AGON_ IST SHOW EFFECTIVE KILLING OF OSTEOSARCOMA PDXOS IN-VITRO
    Deveci, R. Tuna
    Fowler, D.
    Kanouta, A.
    Barisa, M.
    Anderson, J.
    Chester, K.
    Fisher, J.
    HUMAN GENE THERAPY, 2023, 34 (21-22) : A32 - A32
  • [33] Constitutive expression of a chimeric receptor that delivers IL-2/IL-15 signals allows antigen-independent proliferation of CD8+CD44high but not other T cells
    Gasser, S
    Corthésy, P
    Beerman, F
    MacDonald, HR
    Nabholz, M
    JOURNAL OF IMMUNOLOGY, 2000, 164 (11): : 5659 - 5667
  • [34] Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models
    Mu-Mosley, Hong
    Ostermann, Lauren
    Muftuoglu, Muharrem
    Vaidya, Abishek
    Bonifant, Challice L.
    Velasquez, Mireya Paulina
    Gottschalk, Stephen
    Andreeff, Michael
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [35] T Cells engineered to express the IL-13Rα2 specific CAR and a PD-L1 specific switch receptor show increased anti-tumor activity in the Glioblastoma tumor microenvironment
    De Castro, Abel
    Keys, Megan E.
    Arroyo, Jonathan
    Prosser, Megan E.
    CANCER RESEARCH, 2018, 78 (13)
  • [36] Constitutive expression of a chimeric receptor that delivers IL-2/IL-15 signals allows antigen-independent proliferation of CD8+CD44high but not other T cells (vol 164, pg 5659, 2000)
    Gasser, S
    Corthésy, P
    Beerman, F
    MacDonald, HR
    Nabholz, M
    JOURNAL OF IMMUNOLOGY, 2000, 165 (04): : 2313 - 2313
  • [37] Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity
    Kaufman, Dan S.
    Bjordahl, Ryan
    Zhu, Huang
    Blum, Robert
    Bahena, Andres
    Mahmood, Sajid
    Bonello, Greg
    Lee, Tom
    Walcheck, Bruce
    Cichocki, Frank
    Miller, Jeffrey S.
    Valamehr, Bahram
    BLOOD, 2018, 132