A High Expression of IL15 Receptor Alpha (IL15Rα) in Glioblastoma Microenvironment Enables IL15-Armored CAR T Cells to Modulate Tumor Immunosuppression and Improve Survival in Syngeneic Models

被引：0
|
作者：
Zannikou, Markella [1 ]
Duffy, Joseph T. [2 ]
Levine, Rebecca N. [2 ]
Seblani, Maggie D. [2 ]
Liu, Iris [2 ]
Arrieta, Victor A. [2 ]
Sonabend, Adam M. [2 ]
Lee-Chang, Catalina [2 ]
Miska, Jason M. [2 ]
Balyasnikova, Irina V. [2 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Neurol Surg, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
来源：
MOLECULAR THERAPY | 2022年 / 30卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
478
引用
收藏
页码：226 / 227
页数：2
相关论文
共 37 条
  • [21] Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer
    Ye, Jianbin
    Liu, Qiaoyuan
    He, Yunxuan
    Song, Zhenkun
    Lin, Bao
    Hu, Zhiwei
    Hu, Juanyuan
    Ning, Yunshan
    Cai, Cheguo
    Li, Yan
    JOURNAL OF TRANSLATIONAL MEDICINE, 2024, 22 (01)
  • [22] Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer
    Jianbin Ye
    Qiaoyuan Liu
    Yunxuan He
    Zhenkun Song
    Bao Lin
    Zhiwei Hu
    Juanyuan Hu
    Yunshan Ning
    Cheguo Cai
    Yan Li
    Journal of Translational Medicine, 22
  • [23] Expressing IL-15/IL-18 and CXCR2 improve infiltration and survival of EGFRvIII-targeting CAR-T cells in breast cancer
    Sun, Ruixin
    Liu, Yifan
    Wu, Chuanlong
    Zhou, Min
    Luo, Hong
    Du, Guoxiu
    Liu, Zhengyang
    Sun, Yansha
    Dong, Yiwei
    Su, Jingwen
    Fan, Mingliang
    Shi, Bizhi
    Jiang, Hua
    Li, Zonghai
    BIOCHEMICAL PHARMACOLOGY, 2023, 212
  • [24] Transgenic expression of IL15 selectively expands antigen specific cytotoxic T cells (CTLs) enhancing their anti-tumor effect in vivo.
    Vera, J.
    Quintarelli, C.
    Savoldo, B.
    Giordano, G.
    Foster, A.
    Pule, M.
    Heslop, Helen
    Rooney, C.
    Brenner, Malcolm
    Dotti, G.
    BLOOD, 2006, 108 (11) : 489A - 489A
  • [25] IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner
    Liu, Rebecca Berlant
    Engels, Boris
    Schreiber, Karin
    Ciszewski, Cezary
    Schietinger, Andrea
    Schreiber, Hans
    Jabri, Bana
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (20) : 8158 - 8163
  • [26] Activating chimeric receptor on IL-15 armored NK cells to improve in vitro and in vivo tumor response within the liver following regional delivery.
    Tan, Joanne
    Guha, Prajna
    Wadsworth, Sarah
    Ghosh, Chandra C.
    Chai, Louis F.
    Katz, Steven C.
    Trager, James
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [27] GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
    Gargett, Tessa
    Ebert, Lisa M.
    Truong, Nga T. H.
    Kollis, Paris M.
    Sedivakova, Kristyna
    Yu, Wenbo
    Yeo, Erica C. F.
    Wittwer, Nicole L.
    Gliddon, Briony L.
    Tea, Melinda N.
    Ormsby, Rebecca
    Poonnoose, Santosh
    Nowicki, Jake
    Vittorio, Orazio
    Ziegler, David S.
    Pitson, Stuart M.
    Brown, Michael P.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (09)
  • [28] RLI, a sushi-IL-15Rα/IL-15 fusion protein, is a potent immunomodulatory agent on NK and CD8+T cells and synergizes with anti-PD1 treatment in preclinical mouse tumor models
    Desbois, Melanie
    Beal, Coralie
    Coutzac, Clelia
    Terme, Magali
    Teppaz, Geraldine
    Morisseau, Sebastien
    Bechard, David
    Mortier, Erwan
    Chaput, Nathalie
    CANCER RESEARCH, 2014, 74 (19)
  • [29] Expressing IL-15/IL-18 and CXCR2 improve infiltration and survival of EGFRvIII-targeting CAR-T cells in breast cancer (vol 212, 115536, 2023)
    Sun, Ruixin
    Liu, Yifan
    Wu, Chuanlong
    Zhou, Min
    Luo, Hong
    Du, Guoxiu
    Liu, Zhengyang
    Sun, Yansha
    Dong, Yiwei
    Su, Jingwen
    Fan, Mingliang
    Shi, Bizhi
    Jiang, Hua
    Li, Zonghai
    BIOCHEMICAL PHARMACOLOGY, 2023, 214
  • [30] Enhanced anti-tumor efficacy of "IL-15 and CCL19" -secreting CAR-T cells in human glioblastoma orthotopic xenograft model
    Chen, Wanqiong
    Hong, Limian
    Lin, Shaomei
    Xian, Na
    Yan, Cailing
    Zhao, Ningning
    Xiao, Yonglei
    Liao, Wanting
    Huang, Yuxiang
    Chen, Mingzhu
    FRONTIERS IN ONCOLOGY, 2025, 15
1234