Genetics of Type 1 diabetes mellitus

被引：0
|
作者：
Minárik, P
Camajová, J
Michalková, D
Nazarov, V
机构：
[1] Slovak Acad Sci, Inst Mol Biol, SK-84551 Bratislava, Slovakia
[2] Univ Childrens Hosp, Clin 1, SK-83340 Bratislava, Slovakia
[3] Novo Nordisk AS Bratislava, SK-82102 Bratislava, Slovakia
来源：
BIOLOGIA | 2002年 / 57卷 / 06期
关键词：
diabetes mellitus Type 1; genetics; HLA region; insulin gene;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Diabetes mellitus Type 1 (DM1) is caused by a progressive autoimmune destruction of insulin-producing pancreatic beta-cells. The genetic analysis identified HLA and insulin gene polymorphism as major determinants of susceptibility to this disease. It has been suggested that HLA and insulin loci might account for more than 60 % of the familial DM1 clustering.
引用
收藏
页码：721 / 724
页数：4
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