Engineered clearing agents for the selective depletion of antigen-specific antibodies

被引：31

作者：

Devanaboyina, Siva Charan ^{[1
,2
]}

Khare, Priyanka ^{[1
,2
]}

Challa, Dilip K. ^{[1
,2
]}

Ober, Raimund J. ^{[1
,3
]}

Ward, E. Sally ^{[1
,2
]}

机构：

[1] Texas A&M Univ, Hlth Sci Ctr, Dept Mol & Cellular Med, 469 Joe H Reynolds Med Sci Bldg,1114 TAMU, College Stn, TX 77843 USA

[2] Texas A&M Univ, Hlth Sci Ctr, Dept Microbial Pathogenesis & Immunol, 3107 Med Res & Educ Bldg,8447 State Highway 47, Bryan, TX 77807 USA

[3] Texas A&M Univ, Dept Biomed Engn, 5045 Emerging Technol Bldg,3120 TAMU, College Stn, TX 77843 USA

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NEONATAL FC-RECEPTOR; I-RELATED RECEPTOR; MULTIPLE-SCLEROSIS; NONHUMAN-PRIMATES; IGG; AUTOIMMUNE; REDUCTION; BLOCKADE; DELIVERY;

D O I：

10.1038/ncomms15314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.

引用

页数：6

共 50 条

[1] Engineered clearing agents for the selective depletion of antigen-specific antibodies
Siva Charan Devanaboyina
Priyanka Khare
Dilip K. Challa
Raimund J. Ober
E. Sally Ward
Nature Communications, 8
[2] Selective Depletion of Antigen-Specific Antibodies for the Treatment of Demyelinating Disease
Sun, Wei
Khare, Priyanka
Wang, Xiaoli
Challa, Dilip K.
Greenberg, Benjamin M.
Ober, Raimund J.
Ward, E. Sally
MOLECULAR THERAPY, 2021, 29 (03) : 1312 - 1323
[3] Antigen-specific agents in development
Sznol, M
Holmlund, J
SEMINARS IN ONCOLOGY, 1997, 24 (02) : 173 - 186
[4] Nanoparticles engineered for antigen-specific immunotherapy
Alexandra Flemming
Nature Reviews Immunology, 2016, 16 : 205 - 205
[5] Nanoparticles engineered for antigen-specific immunotherapy
Alexandra Flemming
Nature Reviews Drug Discovery, 2016, 15 : 233 - 233
[6] Nanoparticles engineered for antigen-specific immunotherapy
Flemming, Alexandra
NATURE REVIEWS IMMUNOLOGY, 2016, 16 (04) : 205 - 205
[7] DEPLETION OF ANTIGEN-SPECIFIC LYMPHOCYTE CLONES INVIVO
HAY, JB
CAHILL, RNP
TRNKA, Z
FEDERATION PROCEEDINGS, 1974, 33 (03) : 646 - 646
[8] Microscale purification of antigen-specific antibodies
Brown, Eric P.
Normandin, Erica
Osei-Owusu, Nana Yaw
Mahan, Alison E.
Chan, Ying N.
Lai, Jennifer I.
Vaccari, Monica
Rao, Mangala
Franchini, Genoveffa
Alter, Galit
Ackerman, Margaret E.
JOURNAL OF IMMUNOLOGICAL METHODS, 2015, 425 : 27 - 36
[9] AUTOIMMUNITY Nanoparticles engineered for antigen-specific immunotherapy
Flemming, Alexandra
NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (04) : 233 - 233
[10] SELECTIVE EXPANSION OF ANTIGEN-SPECIFIC CD8 T CELLS WITH ENGINEERED ANTIGEN PRESENTING EXOSOME
Yamano, Tomoyoshi
Lyu, Xiabing
Hanayama, Rikinari
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A743 - A743

← 1 2 3 4 5 →