Engineered clearing agents for the selective depletion of antigen-specific antibodies

被引：31

作者：

Devanaboyina, Siva Charan ^{[1
,2
]}

Khare, Priyanka ^{[1
,2
]}

Challa, Dilip K. ^{[1
,2
]}

Ober, Raimund J. ^{[1
,3
]}

Ward, E. Sally ^{[1
,2
]}

机构：

[1] Texas A&M Univ, Hlth Sci Ctr, Dept Mol & Cellular Med, 469 Joe H Reynolds Med Sci Bldg,1114 TAMU, College Stn, TX 77843 USA

[2] Texas A&M Univ, Hlth Sci Ctr, Dept Microbial Pathogenesis & Immunol, 3107 Med Res & Educ Bldg,8447 State Highway 47, Bryan, TX 77807 USA

[3] Texas A&M Univ, Dept Biomed Engn, 5045 Emerging Technol Bldg,3120 TAMU, College Stn, TX 77843 USA

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NEONATAL FC-RECEPTOR; I-RELATED RECEPTOR; MULTIPLE-SCLEROSIS; NONHUMAN-PRIMATES; IGG; AUTOIMMUNE; REDUCTION; BLOCKADE; DELIVERY;

D O I：

10.1038/ncomms15314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.

引用

页数：6

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