Engineered clearing agents for the selective depletion of antigen-specific antibodies

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作者：
Siva Charan Devanaboyina
Priyanka Khare
Dilip K. Challa
Raimund J. Ober
E. Sally Ward
机构：
[1] Texas A&M University Health Science Center,Department of Molecular and Cellular Medicine
[2] Texas A&M University Health Science Center,Department of Microbial Pathogenesis and Immunology
[3] Texas A&M University,Department of Biomedical Engineering
来源：
Nature Communications | / 8卷
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摘要：
Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs’) that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.
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