Haplotype analysis in population genetics and association studies

被引：126
|
作者：
Zhao, HY
Pfeiffer, R
Gail, MH
机构：
[1] Yale Univ, Dept Epidemiol & Publ Hlth, Sch Med, New Haven, CT 06520 USA
[2] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
来源：
PHARMACOGENOMICS | 2003年 / 4卷 / 02期
关键词：
complex disease; genetic association; haplotype; linkage disequilibrium; population genetics; LINKAGE DISEQUILIBRIUM; MAXIMUM-LIKELIHOOD; CLADISTIC-ANALYSIS; SEQUENCE VARIATION; HUMAN GENOME; DISEASE; EFFICIENCY; INFERENCE; SUSCEPTIBILITY; RECOMBINATION;
D O I：
10.1517/phgs.4.2.171.22636
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. in this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.
引用
收藏
页码：171 / 178
页数：8
相关论文
共 50 条
  • [31] Detecting haplotype effects in genomewide association studies
    Huang, B. E.
    Amos, C. I.
    Lin, D. Y.
    GENETIC EPIDEMIOLOGY, 2007, 31 (08) : 803 - 812
  • [32] The origin of the transthyretin ile 122 allele: Haplotype analysis and population studies.
    Jacobson, DR
    Schneider, J
    Sobel, M
    Yang, J
    Malendowicz, S
    Sobol, J
    Tufau, P
    Buxbaum, JN
    AMYLOID AND AMYLOIDOSIS 1998, 1999, : 227 - 229
  • [33] Is haplotype tagging the panacea to association mapping studies?
    Ansar Jawaid
    Pak C Sham
    Andrew J Makoff
    Philip J Asherson
    European Journal of Human Genetics, 2004, 12 : 259 - 262
  • [34] Haplotype approach for association analysis on hypertension
    Shen X.
    Espin-Garcia O.
    Qiu X.
    Brhane Y.
    Liu G.
    Xu W.
    BMC Proceedings, 8 (Suppl 1)
  • [35] Haplotype-based association analysis in cohort and nested case-control studies
    Chen, JB
    Chatterjee, N
    BIOMETRICS, 2006, 62 (01) : 28 - 35
  • [36] The genetics of albuminuria: from haplotype association mapping in mice to genetic causation in humans
    Sterken, Roel
    Kiryluk, Krzysztof
    KIDNEY INTERNATIONAL, 2010, 77 (03) : 173 - 175
  • [37] THEORETICAL POPULATION-GENETICS STUDIES
    EWENS, WJ
    TRENDS IN BIOCHEMICAL SCIENCES, 1976, 1 (11) : N247 - N247
  • [38] Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population
    Ikari, K.
    Momohara, S.
    Inoue, E.
    Tomatsu, T.
    Hara, M.
    Yamanaka, H.
    Kamatani, N.
    RHEUMATOLOGY, 2006, 45 (11) : 1345 - 1348
  • [39] Haplotype association analysis of combining unrelated case-control and triads with consideration of population stratification
    Wen, Shu-Hui
    Tsai, Miao-Yu
    FRONTIERS IN GENETICS, 2014, 5
  • [40] STUDIES ON POPULATION GENETICS OF CERULOPLASMIN POLYMORPHISM
    BAJATZADEH, M
    WALTER, H
    HUMANGENETIK, 1969, 8 (02): : 134 - +
12345