Haplotype analysis in population genetics and association studies

被引：126
|
作者：
Zhao, HY
Pfeiffer, R
Gail, MH
机构：
[1] Yale Univ, Dept Epidemiol & Publ Hlth, Sch Med, New Haven, CT 06520 USA
[2] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
来源：
PHARMACOGENOMICS | 2003年 / 4卷 / 02期
关键词：
complex disease; genetic association; haplotype; linkage disequilibrium; population genetics; LINKAGE DISEQUILIBRIUM; MAXIMUM-LIKELIHOOD; CLADISTIC-ANALYSIS; SEQUENCE VARIATION; HUMAN GENOME; DISEASE; EFFICIENCY; INFERENCE; SUSCEPTIBILITY; RECOMBINATION;
D O I：
10.1517/phgs.4.2.171.22636
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. in this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.
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页码：171 / 178
页数：8
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