Three-Component Synthesis of Spiro[indoline-3,4-pyrazolo[3,4-b]pyridines] under Microwave Irradiation

被引：13
|
作者：
Gao, Xia [1 ,2 ]
Yang, Zheng [1 ]
Hao, Wen-Juan [1 ]
Jiang, Bo [1 ]
Tu, Shu-Jiang [1 ]
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China
[2] Jiangsu Prov Xuzhou Pharmaceut Vocat Coll, Xuzhou, Jiangsu, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 04期
关键词：
ONE-POT; STEREOSELECTIVE-SYNTHESIS; HIGHLY EFFICIENT; WATER; INHIBITORS; ALKALOIDS; DISCOVERY; SPIROTRYPROSTATIN; HETEROCYCLES; DERIVATIVES;
D O I：
10.1002/jhet.2840
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A domino three-component strategy with high efficiency for the synthesis of spiro[indoline-3,4-pyrazolo[3,4-b]pyridines] from easily available isatins, pyrazol-5-amines and -ketonitriles under microwave heating. During reaction process, HOAc plays dual roles as reaction media as well as a BrOnsted acid-promoter. Flexible structural modification, broad functional group compatibility and mild reaction conditions make this strategy a useful and attractive process of library generation for drug discovery.
引用
收藏
页码：2434 / 2439
页数：6
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