Synthesis of spiro[indoline-3,1′-quinolizines] and spiro[indoline-3,4′-pyrido[1,2-a]quinolines] via three-component reactions of azaarenes, acetylenedicarboxylate, and 3-methyleneoxindoles

被引：1

作者：

Sun, Jing ^{[1
]}

Gong, Hui ^{[1
]}

Sun, Yan ^{[1
]}

Yan, Chao-Guo ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

MOLECULAR DIVERSITY | 2013年 / 17卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Multicomponent reaction; MCR; Domino reaction; Diels-Alder reaction; Spirooxindole; Isoquinolinuclidine; Spiro[indoline-3,1 '-quinolizines; DIELS-ALDER REACTION; CYCLOADDITION REACTIONS; EFFICIENT SYNTHESIS; FACILE SYNTHESIS; CONSTRUCTION; HETEROCYCLES; STRATEGIES; CARBON;

D O I：

10.1007/s11030-013-9459-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-component reactions of substituted pyridines, dimethyl acetylenedicarboxylates, and 3-phenacylideneoxindoles afforded spiro[indoline-3,1'-quinolizines] in high yields and with high diastereoselectivity. The Diels-Alder reactions of spiro[indoline-3,1'-quinolizines] with maleic anhydride and -phenyl maleimides successfully resulted in polyfunctionalized isoquinolinuclidine derivatives. The similar three-component reactions with quinoline resulted in the novel spiro[indoline-3,4'-pyrido[1,2-a]quinolines] in moderate to good yields.

引用

页码：627 / 639

页数：13

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