Synthesis, characterization, and antitumor properties of ruthenium(II) anthraquinone complexes

被引：20

作者：

Wang, Jin-Quan ^{[1
,2
]}

Zhao, Zi-Zhuo ^{[3
]}

Bo, Hua-Ben ^{[1
]}

Chen, Qi-Zhu ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou, Guangdong, Peoples R China

[2] Guangdong Prov Key Lab Biotechnol Candidate Drug, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2016年 / 69卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Ruthenium(II) complexes; DNA; apoptosis; antitumor; CALF THYMUS DNA; DEOXYRIBONUCLEIC-ACID; ANTICANCER DRUG; PRIMARY TARGET; APOPTOSIS; BINDING; TOXICITY; CYTOTOXICITY; MITOCHONDRIA; POLYPYRIDYL;

D O I：

10.1080/00958972.2015.1120291

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three new Ru(II) complexes, [Ru(dmb)(2)(ipad)](ClO4)(2) (dmb=4,4-dimethyl-2,2-bipyridine, ipad=2-(anthracene-9,10-dione-2-yl) imidazo[4,5-f][1,10]phenanthroline, 1), [Ru(dmp)(2)(ipad)](ClO4)(2) (dmp=2,9-dimethyl-1,10-phenanthroline, 2), and [Ru(dip)(2)(ipad)](ClO4)(2) (dip=4,7-diphenyl-1,10-phenanthroline, 3), have been synthesized and characterized. The three Ru(II) complexes intercalate with the base pairs of DNA. The in vitro antiproliferative activities and apoptosis-inducing characteristics of these complexes were investigated. The complexes exhibited cytotoxicity against various human cancer cell lines. BEL-7402 cells displayed the highest sensitivity to 1, accounted for by the greatest cellular uptake. Complex 1 was shown to accumulate preferentially in the nuclei of BEL-7402 cells and cause DNA damage and induce apoptosis, which involved cell cycle arrest and reactive oxygen species generation. [GRAPHICS]

引用

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页码：177 / 189

页数：13

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