Synthesis, characterization, and antitumor properties of ruthenium(II) anthraquinone complexes

被引：20
|
作者：
Wang, Jin-Quan [1 ,2 ]
Zhao, Zi-Zhuo [3 ]
Bo, Hua-Ben [1 ]
Chen, Qi-Zhu [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Biotechnol Candidate Drug, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2016年 / 69卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Ruthenium(II) complexes; DNA; apoptosis; antitumor; CALF THYMUS DNA; DEOXYRIBONUCLEIC-ACID; ANTICANCER DRUG; PRIMARY TARGET; APOPTOSIS; BINDING; TOXICITY; CYTOTOXICITY; MITOCHONDRIA; POLYPYRIDYL;
D O I：
10.1080/00958972.2015.1120291
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Three new Ru(II) complexes, [Ru(dmb)(2)(ipad)](ClO4)(2) (dmb=4,4-dimethyl-2,2-bipyridine, ipad=2-(anthracene-9,10-dione-2-yl) imidazo[4,5-f][1,10]phenanthroline, 1), [Ru(dmp)(2)(ipad)](ClO4)(2) (dmp=2,9-dimethyl-1,10-phenanthroline, 2), and [Ru(dip)(2)(ipad)](ClO4)(2) (dip=4,7-diphenyl-1,10-phenanthroline, 3), have been synthesized and characterized. The three Ru(II) complexes intercalate with the base pairs of DNA. The in vitro antiproliferative activities and apoptosis-inducing characteristics of these complexes were investigated. The complexes exhibited cytotoxicity against various human cancer cell lines. BEL-7402 cells displayed the highest sensitivity to 1, accounted for by the greatest cellular uptake. Complex 1 was shown to accumulate preferentially in the nuclei of BEL-7402 cells and cause DNA damage and induce apoptosis, which involved cell cycle arrest and reactive oxygen species generation. [GRAPHICS]
引用
收藏
页码：177 / 189
页数：13
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