The enemy within: dormant retroviruses awaken

被引：17
|
作者：
Engel, Michael E. [1 ,2 ,3 ]
Hiebert, Scott W. [4 ]
机构：
[1] Vanderbilt Univ, Sch Med, Monroe Carell Jr Childrens Hosp, Dept Pediat, Nashville, TN 37212 USA
[2] Vanderbilt Univ, Sch Med, Monroe Carell Jr Childrens Hosp, Dept Canc Biol, Nashville, TN 37212 USA
[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA
[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA
来源：
NATURE MEDICINE | 2010年 / 16卷 / 05期
关键词：
GENE;
D O I：
10.1038/nm0510-517
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation-but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571-579).
引用
收藏
页码：517 / 518
页数：2
相关论文
共 50 条
  • [41] Dormant tumors awaken by a short-term angiogenic burst - The spike hypothesis
    Indraccolo, Stefano
    Favaro, Elena
    Amadori, Alberto
    CELL CYCLE, 2006, 5 (16) : 1751 - 1755
  • [42] The enemy within
    Nicola McCarthy
    Nature Reviews Cancer, 2012, 12 : 734 - 734
  • [43] THE ENEMY WITHIN
    COLE, RW
    PHI DELTA KAPPAN, 1987, 69 (02) : 98 - 98
  • [44] THE ENEMY WITHIN
    ANDERSON, CA
    NURSING OUTLOOK, 1994, 42 (04) : 149 - 150
  • [45] The ally within the enemy within
    Dutton G.
    Dutton, Gail, 2016, Mary Ann Liebert Inc. (36): : 8and10
  • [46] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
    Albrengues, Jean
    Shields, Mario A.
    Ng, David
    Park, Chun Gwon
    Ambrico, Alexandra
    Poindexter, Morgan E.
    Upadhyay, Priya
    Uyeminami, Dale L.
    Pommier, Arnaud
    Kuttner, Victoria
    Bruzas, Emilis
    Maiorino, Laura
    Bautista, Carmelita
    Carmona, Ellese M.
    Gimotty, Phyllis A.
    Fearon, Douglas T.
    Chang, Kenneth
    Lyons, Scott K.
    Pinkerton, Kent E.
    Trotman, Lloyd C.
    Goldberg, Michael S.
    Yeh, Johannes T. -H.
    Egeblad, Mikala
    SCIENCE, 2018, 361 (6409) : 1353 - +
  • [47] The press: The enemy within
    Massing, M
    NEW YORK REVIEW OF BOOKS, 2005, 52 (20) : 36 - +
  • [48] NIXON AND ENEMY WITHIN
    LIEBERT, RS
    PSYCHOLOGY TODAY, 1977, 10 (10) : 68 - 69
  • [49] EMI - THE ENEMY WITHIN
    BARON, NT
    CEBULSKI, DR
    NAVAL ENGINEERS JOURNAL, 1992, 104 (02) : 69 - 80
  • [50] The enemy of science is within
    Halestrap, AP
    NATURE, 1996, 379 (6563) : 292 - 292
12345