The enemy within: dormant retroviruses awaken

被引：17

作者：

Engel, Michael E. ^{[1
,2
,3
]}

Hiebert, Scott W. ^{[4
]}

机构：

[1] Vanderbilt Univ, Sch Med, Monroe Carell Jr Childrens Hosp, Dept Pediat, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Monroe Carell Jr Childrens Hosp, Dept Canc Biol, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA

[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 05期

关键词：

GENE;

D O I：

10.1038/nm0510-517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation-but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571-579).

引用

页码：517 / 518

页数：2

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