Palladium-Catalyzed Regioselective C-2 Arylation of Benzofurans with N-Acyl Arylhydrazines

被引：14
|
作者：
Cao, Jun [1 ,3 ]
Chen, Zi-Li [2 ]
Li, Shu-Min [3 ]
Zhu, Gao-Feng [3 ]
Yang, Yuan-Yong [3 ]
Wang, Cong [3 ]
Chen, Wen-Zhang [4 ]
Wang, Jian-Ta [3 ]
Zhang, Ji-Quan [1 ,3 ,4 ]
Tang, Lei [1 ,4 ]
机构：
[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China
[2] Guizhou Med Univ, Affiliated Hosp, Guiyang 550004, Peoples R China
[3] Guizhou Med Univ, Coll Pharm, Guiyang 550025, Peoples R China
[4] Guizhou Med Univ, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550004, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 22期
关键词：
Arylation; Palladium; Benzofurans; Arylhydrazines; Regioselectivity; C-H FUNCTIONALIZATION; BOND FORMATION; DERIVATIVES; INHIBITORS; COMPLEX; OLEFINS; MILD; LEAD;
D O I：
10.1002/ejoc.201800374
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel ligand-free palladium-catalyzed C-2 arylation of benzofurans has been developed using N-acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional-group tolerance and highly regioselective products with good to excellent yields.
引用
收藏
页码：2774 / 2779
页数：6
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