Immunotherapy Against Head and Neck Cancer Stem Cells

被引：0

作者：

Coordes, Annekatrin ^{[1
]}

Ochsenreither, Sebastian ^{[2
,3
]}

Qian, Xu ^{[1
]}

Hofmann, Veit Maria ^{[1
]}

Meyer, Jens E. ^{[4
]}

Hoffmann, Thomas Karl ^{[5
]}

Kaufmann, Andreas M. ^{[6
]}

Albers, Andreas E. ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Klin Hals Nasen Ohrenheilkunde Kopf & Halschirurg, Campus Benjamin Franklin,Hindenburgdamm 30, D-12200 Berlin, Germany

[2] Charite Univ Med Berlin, Klin Hamatol Onkol & Tumorimmunol, Campus Benjamin Franklin, Berlin, Germany

[3] Charite Univ Med Berlin, Charite Comprehens Canc Ctr, Berlin, Germany

[4] AK St Georg Hamburg, Abt Hals Nasen Ohrenheilkunde Kopf & Halschirurg, Hamburg, Germany

[5] Univ Ulm, Kopf & Hals Chirurg, Ohrenklin, Hals,Nasen, Ulm, Germany

[6] Charite Univ Med Berlin, Gynakol, Gynakol Tumorimmunol, Berlin, Germany

来源：

LARYNGO-RHINO-OTOLOGIE | 2017年 / 96卷 / 04期

关键词：

squamous cell cancer of the head and neck; epithelial-mesenchymal transition; cancer stem cell; human papilloma virus; immunotherapy; PD-L1; TO-MESENCHYMAL TRANSITION; INITIATING CELLS; HUMAN-PAPILLOMAVIRUS; PROSTATE-CANCER; SELF-RENEWAL; ANTITUMOR IMMUNITY; SQUAMOUS CARCINOMA; IN-VITRO; ANTIGEN; IDENTIFICATION;

D O I：

10.1055/s-0043-101698

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Immunotherapy against head and neck cancer stem cells Immunologic therapies like antibodies in solid tumors like squamous cell cancer of the head and neck are administered either alone or in combination with radiation and chemotherapy. Despite some respectable successes, the effect of this therapy reaches its limits due the ability of the tumor to escape the immune system. Cancer stem cells seem to play an important role in this process due to their intrinsic resistance to conventional therapy and the ability to regenerate tumor heterogeneity. This way they substantially contribute to the formation of recurrences and metastases. Therefore, future immunotherapies should target specifically this subpopulation, possibly in combination with other therapeutic modalities. In this review the immunologic features of cancer stem cells and their potential as target for immunotherapies is summarized.

引用

页码：216 / 224

页数：9

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