Immunotherapy for Head and Neck Cancer

被引：19

作者：

Sim, Felix ^{[1
,2
,3
]}

Leidner, Rom ^{[4
]}

Bell, Richard Bryan ^{[4
,5
]}

机构：

[1] Royal Melbourne Hosp, Dept Oral & Maxillofacial Surg, 300 Grattan St, Parkville, Vic 3050, Australia

[2] Monash Hlth, Dept Oral & Maxillofacial Surg, 823 Ctr Rd, Bentleigh East, Vic 3165, Australia

[3] Barwon Hlth, Oral & Maxillofacial Surg Unit, Ryrie St & Bellerine St, Geelong, Vic 3220, Australia

[4] Providence Canc Inst, Earle A Chiles Res Inst, Robert W Franz Canc Ctr, Providence Portland Med Ctr, 4805 Northeast Glisan St,Suite 2N35, Portland, OR 97213 USA

[5] Head & Neck Inst, 1849 NW Kearney,Suite 300, Portland, OR 97209 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 02期

关键词：

Head and neck cancer; Squamous cell carcinoma; Immunotherapy; Checkpoint inhibitor; Oncolytic virus; Adoptive T-cell transfer; SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; T-CELLS; PD-1; BLOCKADE; EX-VIVO; IN-VIVO; MONOCLONAL-ANTIBODIES; HUMAN-PAPILLOMAVIRUS; ANTITUMOR IMMUNITY; CLINICAL ACTIVITY;

D O I：

10.1016/j.hoc.2018.12.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides an overview of the interaction between immune infiltrating cells in the tumor microenvironment, and the immunologic principles related to HNSCC. Current immunotherapeutic strategies and emerging results from ongoing clinical trials are presented.

引用

页码：301 / +

页数：22

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