Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor

被引：65

作者：

Kang, Kyoung Ah

Lee, Kyoung Hwa

Park, Jae Woo

Lee, Nam Ho

Na, Hye Kyung

Surh, Young Joon

You, Ho Jin

Chung, Myung Hee

Hyun, Jin Won ^{[1
]}

机构：

[1] Jeju Natl Univ, Dept Biochem, Coll Med, Cheju 690756, South Korea

[2] Jeju Natl Univ, Appl Radiol Sci Res Inst, Cheju 690756, South Korea

[3] Jeju Natl Univ, Dept Nucl & Energy Engn, Cheju 690756, South Korea

[4] Jeju Natl Univ, Dept Chem, Coll Nat Sci, Cheju 690756, South Korea

[5] Seoul Natl Univ, Coll Pharm, Lab Biochem & Mol Toxicol, Seoul 151742, South Korea

[6] Chosun Univ, Coll Med, Dept Pharmacol, Kwangju 501759, South Korea

[7] Seoul Natl Univ, Coll Med, Dept Pharmacol, Seoul 110799, South Korea

来源：

FEBS LETTERS | 2007年 / 581卷 / 10期

关键词：

triphlorethol-A; heme oxygenase-1; NF-E2 related factor 2; antioxidant response element;

D O I：

10.1016/j.febslet.2007.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triphlorethol-A, phlorotannin found in Ecklonia cava, induced heine oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-I activity. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol-A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol-A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol-A induced activation of Nrf2, finally decreased HO-1 protein level. Taken together, these data suggest that triphlorethol-A augments cellular antioxidant defense capacity through induction of HO-I via ERK-Nrf2-ARE signaling pathway, thereby protecting cells from oxidative stress. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2000 / 2008

页数：9

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