Formal total synthesis of selaginpulvilin D

被引：24
|
作者：
Chinta, Bhavani Shankar [1 ]
Baire, Beeraiah [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 28期
关键词：
4+2 CYCLOADDITION REACTIONS; DIELS-ALDER REACTION; CONJUGATED ENYNES; CYCLOAROMATIZATION; DERIVATIVES; FIELD;
D O I：
10.1039/c7ob00950j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and mild synthetic strategy for the total synthesis of selaginpulvilin D has been reported. A highly chemoselective enyne-alkyne dehydro Diels-Alder reaction has been employed for the construction of the tricyclic fluorene framework present in the natural product selaginpulvilin D. An improved overall yield (10.5%) has been achieved for selaginpulvilin D, starting from commercially available m-anisaldehyde in 9 linear, operationally simple synthetic transformations.
引用
收藏
页码：5908 / 5911
页数：4
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