Formal total synthesis of selaginpulvilin D

被引：24

作者：

Chinta, Bhavani Shankar ^{[1
]}

Baire, Beeraiah ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 28期

关键词：

4+2 CYCLOADDITION REACTIONS; DIELS-ALDER REACTION; CONJUGATED ENYNES; CYCLOAROMATIZATION; DERIVATIVES; FIELD;

D O I：

10.1039/c7ob00950j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and mild synthetic strategy for the total synthesis of selaginpulvilin D has been reported. A highly chemoselective enyne-alkyne dehydro Diels-Alder reaction has been employed for the construction of the tricyclic fluorene framework present in the natural product selaginpulvilin D. An improved overall yield (10.5%) has been achieved for selaginpulvilin D, starting from commercially available m-anisaldehyde in 9 linear, operationally simple synthetic transformations.

引用

页码：5908 / 5911

页数：4

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