Polymorphisms of the γ-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico

被引：20
|
作者：
Organista-Nava, Jorge [1 ]
Gomez-Gomez, Yazmin [1 ]
Virginia Saavedra-Herrera, Monica [1 ]
Rivera-Ramirez, Bertha [2 ]
Antonio Teran-Porcayo, Marco [2 ]
del Carmen Alarcon-Romero, Luz [3 ]
Illades-Aguiar, Berenice [1 ]
Antonio Leyva-Vazquez, Marco [1 ]
机构：
[1] Univ Autonoma Guerrero, Unidad Acad Ciencias Quim Biol, Lab Biomed Mol, Chilpancingo 39090, Guerrero, Mexico
[2] Inst Estatal Cancerol Arturo Beltron Ortega, Acapulco, Guerrero, Mexico
[3] Univ Autonoma Guerrero, Unidad Acad Ciencias Quim Biol, Lab Citopatol, Chilpancingo 39090, Guerrero, Mexico
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 06期
关键词：
Acute lymphoblastic leukemia; gamma-Glutamyl hydrolase; Risk of relapse; Single nucleotide polymorphism; -401C/T polymorphism; +452C/T polymorphism; SINGLE-NUCLEOTIDE POLYMORPHISMS; REDUCED FOLATE CARRIER; RHEUMATOID-ARTHRITIS; COMMON POLYMORPHISMS; METHOTREXATE; PATHWAY; EXPRESSION; PROMOTER; TISSUES; RNA;
D O I：
10.1016/j.leukres.2009.11.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p = 0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：728 / 732
页数：5
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