Polymorphisms of the γ-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico

被引：20
|
作者：
Organista-Nava, Jorge [1 ]
Gomez-Gomez, Yazmin [1 ]
Virginia Saavedra-Herrera, Monica [1 ]
Rivera-Ramirez, Bertha [2 ]
Antonio Teran-Porcayo, Marco [2 ]
del Carmen Alarcon-Romero, Luz [3 ]
Illades-Aguiar, Berenice [1 ]
Antonio Leyva-Vazquez, Marco [1 ]
机构：
[1] Univ Autonoma Guerrero, Unidad Acad Ciencias Quim Biol, Lab Biomed Mol, Chilpancingo 39090, Guerrero, Mexico
[2] Inst Estatal Cancerol Arturo Beltron Ortega, Acapulco, Guerrero, Mexico
[3] Univ Autonoma Guerrero, Unidad Acad Ciencias Quim Biol, Lab Citopatol, Chilpancingo 39090, Guerrero, Mexico
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 06期
关键词：
Acute lymphoblastic leukemia; gamma-Glutamyl hydrolase; Risk of relapse; Single nucleotide polymorphism; -401C/T polymorphism; +452C/T polymorphism; SINGLE-NUCLEOTIDE POLYMORPHISMS; REDUCED FOLATE CARRIER; RHEUMATOID-ARTHRITIS; COMMON POLYMORPHISMS; METHOTREXATE; PATHWAY; EXPRESSION; PROMOTER; TISSUES; RNA;
D O I：
10.1016/j.leukres.2009.11.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p = 0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：728 / 732
页数：5
相关论文
共 50 条
  • [31] Analysis of relapse factors and risk assessment of adult acute lymphoblastic leukemia
    陈培翠
    China Medical Abstracts(Internal Medicine), 2014, 31 (01) : 56 - 56
  • [32] Obesity and risk of relapse in patients with Acute Lymphoblastic Leukemia: A retrospective study
    Ramos-Penafiel, Christian Omar
    Bejarano-Rosales, Monica Patricia
    Gallardo-Rodriguez, Adan German
    Perez-Samano, Daniela
    Leyton-Rivera, Hugo Roberto
    Olarte-Carrillo, Irma
    Martinez-Tovar, Adolfo
    Tarlovsky, Vanessa Fuchs
    Barranco-Lampon, Gilberto
    Alvarez-Altamirano, Karolina
    REVISTA MEDICA DE CHILE, 2023, 151 (05) : 600 - 609
  • [33] Risk Factors for Relapse of Childhood B Cell Acute Lymphoblastic Leukemia
    Zhang, Rongrong
    Zhu, Haiyan
    Yuan, Yufang
    Zhao, Jiou
    Yang, Xiaochun
    Tian, Zhaofang
    MEDICAL SCIENCE MONITOR, 2020, 26
  • [34] Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
    Karol, S. E.
    Larsen, E.
    Cheng, C.
    Cao, X.
    Yang, W.
    Ramsey, L. B.
    Fernandez, C. A.
    McCorkle, J. R.
    Paugh, S. W.
    Autry, R. J.
    Lopez-Lopez, E.
    Diouf, B.
    Jeha, S.
    Pui, C-H
    Raetz, E. A.
    Winick, N. J.
    Carroll, W. L.
    Hunger, S. P.
    Loh, M. L.
    Devidas, M.
    Evans, W. E.
    Yang, J. J.
    Relling, M. V.
    LEUKEMIA, 2017, 31 (06) : 1325 - 1332
  • [35] Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
    S E Karol
    E Larsen
    C Cheng
    X Cao
    W Yang
    L B Ramsey
    C A Fernandez
    J R McCorkle
    S W Paugh
    R J Autry
    E Lopez-Lopez
    B Diouf
    S Jeha
    C-H Pui
    E A Raetz
    N J Winick
    W L Carroll
    S P Hunger
    M L Loh
    M Devidas
    W E Evans
    J J Yang
    M V Relling
    Leukemia, 2017, 31 : 1325 - 1332
  • [36] Risk factors for relapse in childhood acute lymphoblastic leukemia: prediction and prevention
    Ceppi, Francesco
    Cazzaniga, Giovanni
    Colombini, Antonella
    Biondi, Andrea
    Conter, Valentino
    EXPERT REVIEW OF HEMATOLOGY, 2015, 8 (01) : 57 - 70
  • [37] Gene expression profiles identify early relapse in standard risk pediatric acute lymphoblastic leukemia.
    Henry, M
    Reaman, G
    Brown, K
    Mintz, M
    Mitchell, S
    Catchpoole, D
    Stephan, D
    BLOOD, 2003, 102 (11) : 366A - 366A
  • [38] NBN GENE VARIABILITY IS ASSOCIATED WITH INCREASED RISK OF CNS RELAPSE AMONG CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
    Tomasik, B.
    Pastorczak, A.
    Fendler, W.
    Braun, M.
    Madzio, J.
    Taha, J.
    Romiszewska, M.
    Matysiak, M.
    Katarzyna, D.
    Lejman, M.
    Kowalczyk, J.
    Badowska, W.
    Kazanowska, B.
    Szczepanski, T.
    Styczynski, J.
    Trelinska, J.
    Zalewska-Szewczyk, B.
    Irga-Jaworska, N.
    Mlynarski, W.
    HAEMATOLOGICA, 2016, 101 : 201 - 201
  • [39] Evaluating the Effect of 3 Glucocorticoid Receptor Gene Polymorphisms on Risk of Relapse in 100 Iranian Children With Acute Lymphoblastic Leukemia: A Case-Control Study
    Namazi, Soha
    Zareifar, Soheila
    Monabati, Ahmad
    Ansari, Shahla
    Karimzadeh, Iman
    CLINICAL THERAPEUTICS, 2011, 33 (03) : 280 - 290
  • [40] IMMUNOREGULATORY GENE POLYMORPHISMS AND CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) SUSCEPTIBILITY
    Ucisik-Akkaya, Esma
    Davis, Charronne F.
    Do, Thuy N.
    Dorak, M. Tevfik
    HUMAN IMMUNOLOGY, 2009, 70 : S118 - S118
12345