Lactic Acidosis Associated With Metformin in a Patient With Type 2 Diabetes With No Contraindication

被引：2
|
作者：
Dora, Jose Miguel [1 ]
de Souza, Livia H. [1 ]
de Azevedo, Mirela J. [1 ]
Gross, Jorge L. [1 ]
机构：
[1] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Endocrinol, Div Endocrine, BR-90035003 Porto Alegre, RS, Brazil
来源：
ENDOCRINOLOGIST | 2009年 / 19卷 / 06期
关键词：
metformin; biguanides; lactic acidosis; type; 2; diabetes; OUTCOMES;
D O I：
10.1097/TEN.0b013e3181bf1e2e
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Metformin is a frequent treatment for overweight type 2 patients with diabetes. Lactic acidosis (LA) is considered to be a rare, but potentially lethal adverse event associated with metformin. We describe a 52-year-old diabetic patient, with no contra indication to metformin, who had an unequivocal episode of LA related to the drug. After intensive supportive treatment, a fast recovery was observed. Considering putative benefits attributed to metformin, contraindications to this drug are being debated. The association of metformin with LA should be kept in mind when dealing with acute situations such as that presented by the patient described.
引用
收藏
页码：250 / 250
页数：1
相关论文
共 50 条
  • [21] METFORMIN ASSOCIATED LACTIC ACIDOSIS
    Lufungula, Axel Ibalanky
    Tabbi, Wided
    Belenfant, Xavier
    Das, Vincent
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2018, 33 : 51 - 51
  • [22] Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin
    Brassoe, R
    Elkmann, T
    Hempel, M
    Gravholt, CH
    DIABETIC MEDICINE, 2005, 22 (10) : 1451 - 1453
  • [23] A new perspective on the biguanide, metformin therapy in type 2 diabetes and lactic acidosis
    Hotta, Nigishi
    JOURNAL OF DIABETES INVESTIGATION, 2019, 10 (04) : 906 - 908
  • [24] Review: Metformin does not increase risk for lactic acidosis in type 2 diabetes
    Tsapas, Apostolos
    ANNALS OF INTERNAL MEDICINE, 2010, 153 (02)
  • [25] METFORMIN ASSOCIATED LACTIC ACIDOSIS
    Wang, Xuexiang
    Mohottige, Dinushika
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2022, 79 (04) : S100 - S100
  • [26] LACTIC ACIDOSIS ASSOCIATED TO METFORMIN
    Zavala Portugal, Maria Juliana
    Hervias Marquina, Sergio Edmundo
    Palacios Guillen, Alaciel Melissa
    REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE, 2017, 37 (02): : 119 - 122
  • [27] Epidemiology of Lactic Acidosis in Type 2 Diabetes Patients Treated with Metformin in Japan
    Chang, Chia-Hsien
    Sakaguchi, Motonobu
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2015, 24 : 361 - 362
  • [28] Metformin-associated lactic acidosis in a patient with liver disease
    Edwards, CMB
    Barton, MA
    Snook, J
    David, M
    Mak, VHF
    Chowdhury, TA
    QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2003, 96 (04) : 315 - 316
  • [29] Vision Loss in a Patient with Metformin-Associated Lactic Acidosis
    Kreshak, A. A.
    Clark, R. F.
    CLINICAL TOXICOLOGY, 2009, 47 (07) : 726 - 726
  • [30] Metformin-Associated Lactic Acidosis in a Peritoneal Dialysis Patient
    Almaleki, Najlaa
    Ashraf, Mohammad
    Hussein, Majdi M.
    Mohiuddin, Syed A.
    SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION, 2015, 26 (02) : 325 - 328
12345