Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados

被引：16

作者：

Ninh Thi Ngoc ^{[1
,2
]}

Tran Thi Hong Hanh ^{[1
]}

Nguyen Van Thanh ^{[1
]}

Do Thi Thao ^{[3
]}

Nguyen Xuan Cuong ^{[1
,2
]}

Nguyen Hoai Nam ^{[1
,2
]}

Do Cong Thung ^{[4
]}

Phan Van Kiem ^{[1
]}

Chau Van Minh ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Adv Ctr Bioorgan Chem, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam

[2] VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam

[3] VAST, Inst Biotechnol, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam

[4] VAST, Inst Marine Environm & Resources, 246 Da Nang, Haiphong 180000, Vietnam

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2017年 / 65卷 / 06期

关键词：

Sinularia leptoclados; Alcyoniidae; soft coral; steroid; cytotoxic activity; MARINE STEROLS; DERIVATIVES; SEA; CONSTITUENTS; METABOLITES;

D O I：

10.1248/cpb.c17-00129

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6 beta-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50=21.13 +/- 0.70 mu M) and colon adenocarcinoma (SW480, IC50=28.65 +/- 1.53 mu M) cell lines were observed for 1 and against acute leukemia (HL-60, IC50=20.53 +/- 2.26 mu M) and SW480 (IC50=26.61 +/- 1.59 mu M for ergost-5-en-3 beta,7 beta-diol (8). In addition, 3 beta,7 beta-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC50 values ranging from 13.45 +/- 1.81 to 29.01 +/- 3.21 mu M.

引用

页码：593 / 597

页数：5

共 50 条

[21] Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla
Tammam, Mohamed A.
Rarova, Lucie
Kvasnicova, Marie
Gonzalez, Gabriel
Emam, Ahmed M.
Mahdy, Aldoushy
Strnad, Miroslav
Ioannou, Efstathia
Roussis, Vassilios
MARINE DRUGS, 2020, 18 (12)
[22] STUDIES OF AUSTRALIAN SOFT CORALS .9. NOVEL NOR-DITERPENE FROM SOFT CORAL SINULARIA-LEPTOCLADOS
BOWDEN, BF
COLL, JC
MITCHELL, SJ
MULDER, J
STOKIE, GJ
AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (09) : 2049 - 2056
[23] A novel cytotoxic norditerpenoid from the Formosan soft coral Sinularia inelegans
Duh, CY
Wang, SK
Chia, MC
Chiang, MY
TETRAHEDRON LETTERS, 1999, 40 (33) : 6033 - 6035
[24] A novel cytotoxic biscembranoid from the formosan soft coral Sinularia flexibilis
Duh, CY
Wang, SK
Tseng, HK
Sheu, JH
TETRAHEDRON LETTERS, 1998, 39 (39) : 7121 - 7122
[25] Cytotoxic and Antifungal Terpenoids from Bornean Soft Coral, Sinularia flexibilis
Kamada, Takashi
Phan, Chin-Soon
Hamada, Toshiyuki
Hatai, Kishio
Vairappan, Charles Santhanaraju
NATURAL PRODUCT COMMUNICATIONS, 2018, 13 (01) : 17 - 19
[26] Cytotoxic acylated spermidine from a soft coral, Sinularia sp.
Choi, YH
Schmitz, FJ
JOURNAL OF NATURAL PRODUCTS, 1997, 60 (05): : 495 - 496
[27] A cytotoxic 5α,8α-epidioxysterol from a soft coral Sinularia species
Sheu, JH
Chang, KC
Duh, CY
JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01): : 149 - 151
[28] A cytotoxic lobane diterpene from the formosan soft coral Sinularia inelegans
Chai, MC
Wang, SK
Dai, CF
Duh, CY
JOURNAL OF NATURAL PRODUCTS, 2000, 63 (06): : 843 - 844
[29] Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi
Ngoc Ninh Thi
Hanh Tran Thi Hong
Quang Tran Hong
Cuong Nguyen Xuan
Nam Nguyen Hoai
Thao Do Thi
Thung Do Cong
Kiem Phan Van
Minh Chau Van
STEROIDS, 2021, 176
[30] METABOLITES FROM 2 SOFT CORALS FROM GUAM - SINULARIA-LEPTOCLADOS AND SINULARIA-GYROSA
LAKSHMI, V
SCHMITZ, FJ
JOURNAL OF NATURAL PRODUCTS, 1986, 49 (04): : 728 - 730

← 1 2 3 4 5 →