Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi

Fourteen polyhydroxylated steroids including six new compounds, ehrensteroids A - F (1-6), were isolated from the Vietnamese soft coral Sarcophyton ehrenbergi after applying various chromatographic separations. The structure elucidation was done by detailed analysis of 1D, 2D NMR and HR QTOF mass spectra. In addition, significant cytotoxicity (IC50 values ranging from 8.45 +/- 0.56 to 38.27 +/- 2.39 mu M) against all five tested cancer cell lines as LU-1 (lung cancer), HepG2 (hepatoma cancer), MCF-7 (breast cancer), HL-60 (acute leukemia), and SW480 (colon adenocarcinoma) was observed for compounds 1, 2, 6-10, and 12-14, whereas this activity on LU-1 (IC50 = 21.91 +/- 2.72 mu M) and HepG2 (IC50 = 20.32 +/- 0.03 mu M) cell lines was also observed for 4.