Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi

被引：13

作者：

Cheng, Shi-Yie ^{[1
]}

Wang, Shang-Kwei ^{[2
]}

Hsieh, Mu-Keng ^{[3
]}

Duh, Chang-Yih ^{[3
,4
]}

机构：

[1] Natl Univ Kaohsiung, Dept Life Sci, Kaohsiung 811, Taiwan

[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung 807, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 03期

关键词：

ABSOLUTE-CONFIGURATION; CRASSOCAULE; DERIVATIVES; PRECURSOR; TERPENES; PRODUCTS; SKELETON; GLAUCUM;

D O I：

10.3390/ijms16036140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1-5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 mu M, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50 values of 25.0 mu g/mL.

引用

页码：6140 / 6152

页数：13

共 50 条

[1] New Diterpenoids from Soft Coral Sarcophyton ehrenbergi
Wang, Shang-Kwei
Hsieh, Mu-Keng
Duh, Chang-Yih
[J]. MARINE DRUGS, 2013, 11 (11): : 4318 - 4327
[2] New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi
Tang, Gui-Hua
Sun, Zhang-Hua
Zou, Yi-Hong
Yin, Sheng
[J]. MOLECULES, 2016, 21 (05)
[3] Cembrane diterpenoids from the Taiwanese soft coral Sarcophyton stolidotum
Cheng, Yuan-Bin
Shen, Ya-Ching
Kuo, Yao-Haur
Khalil, Ashraf Taha
[J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (07): : 1141 - 1145
[4] Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
Mohamed, Tarik A.
Elshamy, Abdelsamed, I
Abd El-Razek, Mohamed H.
Abdel-Tawab, Asmaa M.
Ali, Sherin K.
Aboelmagd, Mohamed
Suenaga, Midori
Pare, Paul W.
Umeyama, Akemi
Hegazy, Mohamed-Elamir F.
[J]. MOLECULES, 2022, 27 (18):
[5] Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi
Li, Geng
Li, Heng
Tang, Wei
Yao, Li-Gong
Liang, Lin-Fu
Guo, Yue-Wei
[J]. BIOORGANIC CHEMISTRY, 2020, 101
[6] Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis
Li, Songwei
Ye, Fei
Zhu, Zhengdan
Huang, Hui
Mao, Shuichun
Guo, Yuewei
[J]. ACTA PHARMACEUTICA SINICA B, 2018, 8 (06) : 944 - 955
[7] Two new cembrane-type diterpenoids from Okinawan soft coral of the genus, Sarcophyton
Miyaoka, H
Taira, S
Mitome, H
Iguchi, K
Matsumoto, K
Yokoo, C
Yamada, Y
[J]. CHEMISTRY LETTERS, 1996, (03) : 239 - 240
[8] Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis
Songwei Li
Fei Ye
Zhengdan Zhu
Hui Huang
Shuichun Mao
Yuewei Guo
[J]. Acta Pharmaceutica Sinica B, 2018, 8 (06) : 944 - 955
[9] Sarcoehrenbergilides D-F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
Elshamy, Abdelsamed, I
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Ohta, Shinji
Umeyama, Akemi
Pare, Paul W.
Efferth, Thomas
[J]. RSC ADVANCES, 2019, 9 (47) : 27183 - 27189
[10] Cembranoids from the Vietnamese soft coral Sarcophyton ehrenbergi
Ninh Thi, Ngoc
Tran Thi Hong, Hanh
Tran Hong, Quang
Nguyen Xuan, Cuong
Nguyen Hoai, Nam
Thi Thao, Do
Cuong, Pham Van
Do Cong, Thung
Phan Van, Kiem
Van Minh, Chau
[J]. NATURAL PRODUCT RESEARCH, 2022, 36 (21) : 5517 - 5523

← 1 2 3 4 5 →