New Strategy for the Synthesis of Heterocycles via Copper-Catalyzed Oxidative Decarboxylative Amination of Glyoxylic Acid

被引：5

作者：

Niu, Bin ^{[1
]}

Li, Shaoqing ^{[1
]}

Cui, Chang ^{[1
]}

Yan, Yizhe ^{[1
]}

Tang, Lin ^{[3
]}

Wang, Jianyong ^{[2
]}

机构：

[1] Zhengzhou Univ Light Ind, Henan Key Lab Cold Chain Food Qual & Safety Contr, Henan Collaborat Innovat Ctr Food Prod & Safety, Sch Food & Biol Engn, Zhengzhou 450000, Henan, Peoples R China

[2] Qilu Univ Technol, Shandong Acad Sci, Sch Light Ind & Engn, Jinan 250353, Shandong, Peoples R China

[3] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 48期

基金：

中国国家自然科学基金;

关键词：

Glyoxylic acid; Copper; Decarboxylation; C-N coupling; Heterocycles; BOND FORMATION; ARYL HALIDES; FUNCTIONALIZATION; QUINAZOLINONES; FORMYLATION; 1,3,5-TRIAZINES; HYDROFORMYLATION; ACTIVATION; INHIBITORS; QUINOLINE;

D O I：

10.1002/ejoc.201901538

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed oxidative decarboxylative amination of glyoxylic acid with substrates having two nitrogen-nucleophilic sites was first demonstrated. Using this novel approach, 1,3,5-triazines, quinazolinones and quinazolines were obtained in up to 93 % yields. Notably, glyoxylic acid was employed as the C1 synthon for heterocycles. This strategy enriches the application of glyoxylic acid for the synthesis of valuable heterocycles.

引用

页码：7800 / 7803

页数：4

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