Copper-Catalyzed Oxidative Multicomponent Annulation Reaction for Direct Synthesis of Quinazolinones via an Imine-Protection Strategy

被引：28

作者：

Liang, Yantang ^{[1
,2
]}

Tan, Zhenda ^{[1
,2
]}

Jiang, Huanfeng ^{[1
,2
]}

Zhu, Zhibo ^{[3
]}

Zhang, Min ^{[1
,2
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

[2] South China Univ Technol, Sch Chem & Chem Engn, Guangdong Engn Res Ctr Green Fine Chem, Guangzhou 510640, Guangdong, Peoples R China

[3] Southern Med Univ, Integrated Hosp Tradit Chinese Med, 13 Shiliugang Rd, Guangzhou 510315, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 12期

关键词：

CARBONYLATIVE SYNTHESIS; 4-COMPONENT SYNTHESIS; O-AMINOBENZAMIDES; FUNCTIONALIZATION; METAL; 4(3H)-QUINAZOLINONES; CHEMISTRY; ALCOHOLS; HYDROGEN; AMINES;

D O I：

10.1021/acs.orglett.9b01608

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Via an imine-protection strategy, we herein present an unprecedented copper-catalyzed oxidative multicomponent annulation reaction for direct synthesis of quinazolinones. The construction of various products is achieved via formation of three C-N and one C-C bonds in conjunction with the benzylic functionalization. The merits of easily available feedstocks, naturally abundant catalyst, good functional group and substrate compatibility, and release of H2O as the byproduct make the developed chemistry a practical way to access quinazolinones.

引用

页码：4725 / 4728

页数：4

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