CAR-T Cells Targeting Immune Checkpoint Pathway Players

被引：10
|
作者：
Golubovskaya, Vita [1 ]
机构：
[1] Promab Biotechnol, Richmond, CA 94806 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2022年 / 27卷 / 04期
关键词：
CAR-T cell; tumor; checkpoint; immunotherapy; review; CHIMERIC ANTIGEN RECEPTORS; ACUTE MYELOID-LEUKEMIA; TUMOR-CELLS; ANTITUMOR-ACTIVITY; OVARIAN-CANCER; STEM-CELLS; B7; FAMILY; ANTIBODY; IMMUNOTHERAPY; EXPRESSION;
D O I：
10.31083/j.fbl2704121
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CAR (Chimeric antigen receptor)-T cell therapy has become a very promising type of immunotherapy against hematological cancers. This report is focused on CAR-T cells targeting immune checkpoint proteins expressed on tumor cells. The CD70, CD47, CD80, CD86, B7H3, B7H4, PDL-1, TIGIT CAR-T cells and other CAR-T cells are discussed as an effective approach to deplete tumor cells expressing checkpoint proteins. CAR-T cell therapy targeting checkpoint pathways is a promising therapy to decrease inhibitory signaling pathways. The review highlights future directions and perspectives in CAR-T cells targeting immune checkpoint pathways.
引用
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页数：11
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