CAR-T Cells Targeting Immune Checkpoint Pathway Players

被引：10

作者：

Golubovskaya, Vita ^{[1
]}

机构：

[1] Promab Biotechnol, Richmond, CA 94806 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2022年 / 27卷 / 04期

关键词：

CAR-T cell; tumor; checkpoint; immunotherapy; review; CHIMERIC ANTIGEN RECEPTORS; ACUTE MYELOID-LEUKEMIA; TUMOR-CELLS; ANTITUMOR-ACTIVITY; OVARIAN-CANCER; STEM-CELLS; B7; FAMILY; ANTIBODY; IMMUNOTHERAPY; EXPRESSION;

D O I：

10.31083/j.fbl2704121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CAR (Chimeric antigen receptor)-T cell therapy has become a very promising type of immunotherapy against hematological cancers. This report is focused on CAR-T cells targeting immune checkpoint proteins expressed on tumor cells. The CD70, CD47, CD80, CD86, B7H3, B7H4, PDL-1, TIGIT CAR-T cells and other CAR-T cells are discussed as an effective approach to deplete tumor cells expressing checkpoint proteins. CAR-T cell therapy targeting checkpoint pathways is a promising therapy to decrease inhibitory signaling pathways. The review highlights future directions and perspectives in CAR-T cells targeting immune checkpoint pathways.

引用

页数：11

共 50 条

[11] Optimizing efficacy and security of CAR-T cells, and immune monitoring
Lew-Derivry, Lucille
Lamrani, Lamia
Alcantara, Marion
Alanio, Cecile
[J]. M S-MEDECINE SCIENCES, 2024, 40 (05): : 445 - 453
[12] CAR-T: a potential gene carrier targeting solid tumor immune microenvironment
Minjie Wang
Chaocai Zhang
Xiaobing Jiang
[J]. Signal Transduction and Targeted Therapy, 6
[13] CAR-T: a potential gene carrier targeting solid tumor immune microenvironment
Wang, Minjie
Zhang, Chaocai
Jiang, Xiaobing
[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
[14] Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
Martin-Otal, Celia
Lasarte-Cia, Aritz
Serrano, Diego
Casares, Noelia
Conde, Enrique
Navarro, Flor
Sanchez-Moreno, Ines
Gorraiz, Marta
Sarrion, Patricia
Calvo, Alfonso
De Andrea, Carlos E.
Echeveste, Jose
Vilas, Amaia
Rodriguez-Madoz, Juan Roberto
San Miguel, Jesus
Prosper, Felipe
Hervas-Stubbs, Sandra
Lasarte, Juan Jose
Lozano, Teresa
[J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (08)
[15] EVALUATION OF CAR-T CELLS TARGETING CD276 IN MEDULLOBLASTOMA
da Silva, Patricia Benites Goncalves
Sieber, Laura
Mack, Norman
Atar, Daniel
Kutscher, Lena M.
Schlegel, Patrick
Ebinger, Martin
Kawauchi, Daisuke
Seitz, Christian
Pfister, Stefan M.
[J]. NEURO-ONCOLOGY, 2022, 24 : 83 - 83
[16] MRNA TECHNOLOGY FOR THE DEVELOPMENT OF CAR-T CELLS TARGETING FIBROTIC DISEASES
Braeuning, S.
Kitte, R.
Moeser, C.
Schiefer, D.
Greiser, S.
Fricke, S.
Koehl, U.
Tretbar, S.
Blache, U.
[J]. HUMAN GENE THERAPY, 2023, 34 (21-22) : A5 - A5
[17] Probiotic-guided CAR-T cells for solid tumor targeting
Vincent, Rosa L.
Gurbatri, Candice R.
Li, Fangda
Vardoshvili, Ana
Coker, Courtney
Im, Jongwon
Ballister, Edward R.
Rouanne, Mathieu
Savage, Thomas
de los Santos-Alexis, Kenia
Redenti, Andrew
Brockmann, Leonie
Komaranchath, Meghna
Arpaia, Nicholas
Danino, Tal
[J]. SCIENCE, 2023, 382 (6667) : 211 - 218
[18] Novel CAR-T cells targeting TRKB for the treatment of solid cancer
Liang, Dandan
Tang, Jie
Sun, Bin
He, Shuai
Yang, Dong
Ma, Haiyan
Yun, Yuncang
Zhu, Yongjie
Wei, Wenwen
Chen, Haiyang
Zhao, Xudong
[J]. APOPTOSIS, 2024,
[19] The CAR-T cells are here
Croizier, Carolyne
Douge, Aurore
Bay, Jacques-Olivier
Lemal, Richard
[J]. BULLETIN DU CANCER, 2018, 105 (09) : 743 - 745
[20] Engineering CAR-T cells
Zhang, Cheng
Liu, Jun
Zhong, Jiang F.
Zhang, Xi
[J]. BIOMARKER RESEARCH, 2017, 5

← 1 2 3 4 5 →