Innate immune response: ally or enemy in cutaneous leishmaniasis?

被引：3

作者：

Serrano-Coll, Hector ^{[1
,2
]}

Cardona-Castro, Nora ^{[2
]}

Ramos, Ana Pilar ^{[3
]}

Llanos-Cuentas, Alejandro ^{[3
]}

机构：

[1] UNISANGIL, Grp Invest Ciencias Educ & Salud ICES, San Gil, Colombia

[2] Inst Colombiano Med Trop Univ CES, Medellin, Colombia

[3] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander Humboldt, Lima, Peru

来源：

PATHOGENS AND DISEASE | 2021年 / 79卷 / 05期

关键词：

immune system; innate immunity; Leishmania; host-pathogen interaction; infection; NEUTROPHILS; SYSTEM; ACTIVATION; CELLS;

D O I：

10.1093/femspd/ftab028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cutaneous leishmaniasis (CL) is an infectious and neglected disease caused by parasites of the genus Leishmania, which produces a wide spectrum of cutaneous manifestations. CL research has shown that the innate immune activity of cells such as neutrophils, natural killers, macrophages, dendritic cells and the complement system are capable of controlling this infection. However, Leishmania can also modulate the immune activity of these cells to promote its own survival and proliferation at the intracellular level. This review discusses the role of the innate immune response in the control and spread of this infection.

引用

页数：6

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