The innate immune response

被引:51
|
作者
Koenderman, Leo [1 ]
Buurman, Wim [2 ]
Daha, Mohamed R. [3 ]
机构
[1] Univ Med Ctr Utrecht, Dept Resp Med, Utrecht, Netherlands
[2] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci, Maastricht, Netherlands
[3] Leiden Univ, Med Ctr, Dept Nephrol, NL-2300 RA Leiden, Netherlands
关键词
Innate immune response; Cellular and humoral branch; Neuronal regulation; Granulocytes; Complement system; Macrophages; NONNEURONAL CHOLINERGIC SYSTEM; VAGUS NERVE-STIMULATION; PLATELET-ACTIVATING-FACTOR; COMPLEMENT FACTOR-D; HUMAN EOSINOPHILS; IN-VIVO; CHOLECYSTOKININ-RECEPTORS; ANTIINFLAMMATORY PATHWAY; INTESTINAL EPITHELIUM; OPSONIZED PARTICLES;
D O I
10.1016/j.imlet.2014.10.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The innate immune response is of prime importance in the immediate recognition and elimination of invading micro-organisms. However, deregulation of this system is clearly associated with the pathogenesis of a wide range of inflammatory diseases. Innate immunity consists of a humoral and a cellular branch, which are closely interacting. An additional level of control is found at the level of neuronal reflexes that can fine-tune these immunological mechanisms. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:95 / 102
页数:8
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