Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis

被引：51
|
作者：
Oumzil, Khalid [1 ,2 ]
Ramin, Michael A. [1 ,2 ]
Lorenzato, Cyril [3 ]
Hemadou, Audrey [3 ]
Laroche, Jeanny [3 ]
Jacobin-Valat, Marie Josee [3 ]
Mornet, Stephane [4 ]
Roy, Claude-Eric [1 ,2 ]
Kauss, Tina [1 ,2 ]
Gaudin, Karen [1 ,2 ]
Clofent-Sanchez, Gisele [3 ]
Barthelemy, Philippe [1 ,2 ]
机构：
[1] Univ Bordeaux, ARNA Lab, F-33000 Bordeaux, France
[2] INSERM, ARNA Lab, U869, F-33000 Bordeaux, France
[3] Univ Bordeaux, CNRS, Ctr Resonance Magnet Syst Biol, UMR 5536, F-33076 Bordeaux, France
[4] Univ Bordeaux, Inst Chim Matiere Condensee Bordeaux, ICMCB UPR CNRS 9048, F-33608 Pessac, France
来源：
BIOCONJUGATE CHEMISTRY | 2016年 / 27卷 / 03期
关键词：
MAGNETIC-RESONANCE; IN-VIVO; CARDIOVASCULAR-DISEASE; DELIVERY; CANCER; PLAQUE; PROSTACYCLIN; MACROPHAGES; RECEPTOR; FUTURE;
D O I：
10.1021/acs.bioconjchem.5b00590
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.
引用
收藏
页码：569 / 575
页数：7
相关论文
共 50 条
  • [41] Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
    Nakayama, Masao
    Akasaka, Hiroaki
    Miyazaki, Eiichi
    Goto, Yoshihiro
    Oki, Yuya
    Kawate, Yosuke
    Morita, Kenta
    Sasaki, Ryohei
    PHYSICS & IMAGING IN RADIATION ONCOLOGY, 2021, 20 : 94 - 97
  • [42] The design of hybrid nanoparticles for image-guided radiotherapy
    Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS, Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France
    不详
    不详
    不详
    不详
    ACS Symp. Ser., 2012, (95-143):
  • [43] Validation of medical image processing in image-guided therapy
    Jannin, P
    Fitzpatrick, JM
    Hawkes, DJ
    Pennec, X
    Shahidi, R
    Vannier, MW
    IEEE TRANSACTIONS ON MEDICAL IMAGING, 2002, 21 (12) : 1445 - 1449
  • [44] A lipid droplet specific fluorescent probe for image-guided photodynamic therapy under hypoxia
    Zhuang, Weihua
    Tan, Ping
    Li, Shufen
    Li, Chengming
    Zhang, Jiapeng
    Ai, Jianzhong
    Yang, Lu
    Li, Gaocan
    Wei, Qiang
    Chen, Mao
    Wang, Yunbing
    JOURNAL OF MATERIALS CHEMISTRY B, 2021, 9 (46) : 9553 - 9560
  • [45] Deformable registration for image-guided radiation therapy
    Sarrut, David
    ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK, 2006, 16 (04): : 285 - 297
  • [46] Imaging and alignment for image-guided radiation therapy
    Balter, James M.
    Kessler, Marc L.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (08) : 931 - 937
  • [47] Advances in Image-Guided Adaptive Radiation Therapy
    Bertholet, Jenny
    Vinogradskiy, Yevgeniy
    Hu, Yanle
    Carlson, David J.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2021, 110 (03): : 625 - 628
  • [48] Image-guided enzyme/prodrug cancer therapy
    Li, Cong
    Penet, Marie-France
    Winnard, Paul, Jr.
    Artemov, Dmitri
    Bhujwalla, Zaver M.
    CLINICAL CANCER RESEARCH, 2008, 14 (02) : 515 - 522
  • [49] Towards image-guided gene therapy delivery
    Harris, SS
    Gebhart, SC
    Donnelly, E
    Galloway, RL
    SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES, 2002, : 1192 - 1193
  • [50] Radiologists' leading position in image-guided therapy
    Helmberger, Thomas
    Marti-Bonmati, Luis
    Pereira, Philippe
    Gillams, Alice
    Martinez, Jose
    Lammer, Johannes
    Malagari, Katarina
    Gangi, Afshin
    de Baere, Thierry
    Adam, E. Jane
    Rasch, Coen
    Budach, Volker
    Reekers, Jim A.
    INSIGHTS INTO IMAGING, 2013, 4 (01): : 1 - 7
12345