Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis

被引：51

作者：

Oumzil, Khalid ^{[1
,2
]}

Ramin, Michael A. ^{[1
,2
]}

Lorenzato, Cyril ^{[3
]}

Hemadou, Audrey ^{[3
]}

Laroche, Jeanny ^{[3
]}

Jacobin-Valat, Marie Josee ^{[3
]}

Mornet, Stephane ^{[4
]}

Roy, Claude-Eric ^{[1
,2
]}

Kauss, Tina ^{[1
,2
]}

Gaudin, Karen ^{[1
,2
]}

Clofent-Sanchez, Gisele ^{[3
]}

Barthelemy, Philippe ^{[1
,2
]}

机构：

[1] Univ Bordeaux, ARNA Lab, F-33000 Bordeaux, France

[2] INSERM, ARNA Lab, U869, F-33000 Bordeaux, France

[3] Univ Bordeaux, CNRS, Ctr Resonance Magnet Syst Biol, UMR 5536, F-33076 Bordeaux, France

[4] Univ Bordeaux, Inst Chim Matiere Condensee Bordeaux, ICMCB UPR CNRS 9048, F-33608 Pessac, France

来源：

BIOCONJUGATE CHEMISTRY | 2016年 / 27卷 / 03期

关键词：

MAGNETIC-RESONANCE; IN-VIVO; CARDIOVASCULAR-DISEASE; DELIVERY; CANCER; PLAQUE; PROSTACYCLIN; MACROPHAGES; RECEPTOR; FUTURE;

D O I：

10.1021/acs.bioconjchem.5b00590

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.

引用

页码：569 / 575

页数：7

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